Prof. Dr. GABRIELA TĂNASIE

Domenii de interes stiintific

La ora actuala, principala tema de cercetare este reprezentata de studiul fiziologiei celulelor stem si evaluarea plasticitatii acestora, cu aplicabilitate in terapiile celulare. In domeniul medicinei regenerative am urmarit utilizarea celulelor stem mezenchimale in bolile osteo-articulare si boli ale tesuturilor conjunctive investigand metodologia optima de obţinere, cultivare si expandare a celulelor stem mezenchimale din diferite surse.

De asemenea, o serie de studii  au in vedere interacţiunea diverselor biomateriale cu ţesuturile vii, bazat pe studiul biocompatibilitatii in vitro si in vivo, studiul efectului in vitro a unor substanţe si materiale asupra creşterii si diferenţierii celulare.

Ne propunem sa implementam tehnici de bioinginerie tisulara bazate pe utilizarea celulelor in combinatie cu materiale bioactive. Un aspect important este stabilirea unor conditii de cultura in sistem GMP care sa permita utilizarea acestor produse terapeutice in aplicatii clinice.  .

Publicatii stiintifice

1. Oprean C, Zambori C, Borcan F, Soica C, Zupko I, Minorics R, Bojin F, Ambrus R, Muntean D, Danciu C, Pinzaru IA, Dehelean C, Paunescu V, Tanasie G, Anti-proliferative and antibacterial in vitro evaluation of the polyurethane nanostructures incorporating pentacyclic triterpenes, PHARMACEUTICAL BIOLOGY, 2016, 54(11): 2714-2722
2. Anastasiu DM, Cean A, Bojin MF, Gluhovschi A, Panaitescu C, Paunescu V, Tanasie G, Explants-isolated human placenta and umbilical cord cells share characteristics of both epithelial and mesenchymal stem cells, Rom J Morphol Embriol, 2016, 57(2): 383-390
3. Zambori C, Morvay AA, Sala C, Licker M, Gurban C, Tanasie G, Tîrziu E, Antimicrobial effect of probiotics on bacterial species from dental plaque. The journal of infection in developing countries, 2016, 10 (3): 214 – 221
4. Tatu CS, Groza SS, Tatu FR, Bojin MF, Marusciac L, Gavriliuc OI, Hurmuz M, Cean A, Paunescu V, Tanasie G In vivo Functional Studies of Human Adult Mesenchymal Stem Cells Migration towards Inflammatory Lesions after ransfection with CD29 Specific siRNA in Mouse Models Romanian Biotechnological Letters, 2015; 20(6): 11057-66.
5. Csilla Zambori, Attila Alexandru Morvay, Camelia Gurban, Monica Liker, Gabriela Tanasie, Olimpia Colibar, Ciceronis Cumpănășoiu, Cristinel Gigi Șonea, Andra Cristina Șonea, Emil Tirziu, Biofilm formation of Staphylococcus, Streptococcus, Pasteurella and Neisseria strains Romanian Biotechnological Letters, 2015, 20(4): 10718 – 10726
6. Rusu LC, Borţun CM, Tănăsie G, Podariu AC, Baderca F, Solovan C, Ardelean L The cytotoxicity of dental alloys studied on cell culture Rom J Morphol Embryol. 2014;55(1):111-5
7. Ivan, V. Ordodi, A. Cean, D. Ilie, C. Panaitescu, Tanasie. Comparative study of the differentiation potential of rat bone marrow mesenchymal stem cells and rat muscle-derived stem cells Arch. Biol. Sci., Belgrade, 65 (4), 1307-1315, 2013
8. Sava-Rosianu, A. C. Podariu, R. A. Popovici, G. Tanasie, L. Iliuta, R. Oancea. Alveolar bone repair using mesenchymal stem cells placed on granular scaffolds in a rat model. Digest Journal of Nanomaterials and Biostructures, 2013, 8, 1:303 – 311
9. Ivan Boleman A, Tanasie G, Galuscan A, Cristea MI, Bojin FM, Panaitescu C, Paunescu V Studies regarding the in vitro wound healing potential of mouse dental pulp stem-like progenitor cells & Biotec. Eq., 2012; 26(1): 2781-5
10. Sarandan H, Decun M, Paunescu V, Ordodi V, Bojin F, Hutu C, Zarcula S, Burian C, Tanasie G, Sarandan M Deoxynivalenol and Ochratoxin A inactivation in broiler chickens’ feed Romanian Biotechnological Letters, 2012; 17(6): 7825-7834
11. Tanasie G, Bojin F, Ordodi V, Gruia A, Gavriliuc O, Cristea M, Dehelean C, Vintila R, Tatu C, Bunu C, Paunescu V Epithelization of skin lesions in animal model treated with mesenchymal stem cells and derivatives, Romanian Biotechnological Letters, 2011; 16(2): 6072-6080
12. Bojin FM, Gavriliuc OI, Cristea MI, Tanasie G, Tatu CS, Panaitescu C, Paunescu V Telocytes within human skeletal muscle stem cell niche J Cell Mol Med. 2011; 15(10):2269-2272
13. Bojin F, Ordodi V, Anghel S, Gruia A, Gavriliuc O, Georgescu R, Vintila R, Tatu C, Bunu C, Tatu CA, Tanasie G, Paunescu V Mesenchymal stem cells admix with biological scaffold heal bone defects in rat model Romanian Biotechnological Letters, 2011; 16(3): 6218-6225
14. Paunescu V, Bojin FM, Tatu CA, Gavriliuc OI, Rosca A, Gruia AT, Tanasie G, Bunu C, Crisnic D, Gherghiceanu M, Tatu FR, Tatu CS, Vermesan S.Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences J Cell Mol Med. Mar 2011;15(3):635-46.
15. Paunescu V, Deak E, Herman D, Siska IR, Tanasie G,Bunu C, Anghel S, Tatu CA, Oprea TI, Henschler , Rüster B, Bistrian R, Seifried E In vitro Differentiation of Human Mesenchymal Stem Cells to Epithelial Lineage J Cell Mol Med. 2007; 11(3):502-508
16. Lazau, L. Mocanu, I. Miron, P. Sfirloaga, G. Tanasie, C. Tatu, A. Gruia, I. Grozescu. Consideration regarding the use of TiO2 doped nanoparticles in medicine, Digest Journal of Nanomaterials and Biostructures, 2007, 2 (3):257 – 263
17. Ordodi VL, Mic FA, Mic AA, Tanasie G, Ionac M, Sandesc D, Paunescu Bone marrow aspiration from rats: a minimally invasive procedure Lab Anim (NY). 2006 May, 35(5):41-4
18. Paunescu V, Suciu E, Tatu C, Plesa A, Herman D, Siska IR, Suciu C, Crisnic D, Nistor D, Tanasie G, Bunu C, Raica M.Endothelial cells from hematopoietic stem cells are functionally different from those of human umbilical vein, J Cell Mol Med, 2003 7(4):455-60

Afiliere

UMF “Victor Babes” Timisoara, Department III Stiinte Functionale, Disciplina de Fiziologie

Centrul Oncogen -SCJUPB Timisoara