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Professor GABRIELA TĂNASIE, MD, PhD

Professor GABRIELA TĂNASIE, MD, PhD

Senior researcher

Areas of scientific interest
Currently, the main research topic is the study of stem cell physiology and assesment of their plasticity and applicability in cell therapies. In the field of regenerative medicine we study the role of mesenchymal stem cells in restoring bones, joints and other connective tissues, investigating the optimal methodology for harvesting, culture and expansion of mesenchymal stem cells from different sources.

Also, a number of studies evaluate the interaction of various biomaterials with living tissues, based on the in vitro and in vivo biocompatibility testing and in vitro study of the effect of certain substances and materials on growth and cellular differentiation.

We intend to implement tissue bioengineering techniques based on the use of cells in combination with bioactive materials. An important aspect is to establish culture conditions in GMP system allowing the use of such therapeutic products in clinical applications.

 

Relevant publications

  1. Oprean C, Zambori C, Borcan F, Soica C, Zupko I, Minorics R, Bojin F, Ambrus R, Muntean D, Danciu C, Pinzaru IA, Dehelean C, Paunescu V, Tanasie G, Anti-proliferative and antibacterial in vitro evaluation of the polyurethane nanostructures incorporating pentacyclic triterpenes, PHARMACEUTICAL BIOLOGY, 2016, 54(11): 2714-2722
  2. Anastasiu DM, Cean A, Bojin MF, Gluhovschi A, Panaitescu C, Paunescu V, Tanasie G, Explants-isolated human placenta and umbilical cord cells share characteristics of both epithelial and mesenchymal stem cells, Rom J Morphol Embriol, 2016, 57(2): 383-390
  3. Zambori C, Morvay AA, Sala C, Licker M, Gurban C, Tanasie G, Tîrziu E, Antimicrobial effect of probiotics on bacterial species from dental plaque. The journal of infection in developing countries, 2016, 10 (3): 214 – 221
  4. Tatu CS, Groza SS, Tatu FR, Bojin MF, Marusciac L, Gavriliuc OI, Hurmuz M, Cean A, Paunescu V, Tanasie G In vivo Functional Studies of Human Adult Mesenchymal Stem Cells Migration towards Inflammatory Lesions after ransfection with CD29 Specific siRNA in Mouse Models Romanian Biotechnological Letters, 2015; 20(6): 11057-66.
  5. Csilla Zambori, Attila Alexandru Morvay, Camelia Gurban, Monica Liker, Gabriela Tanasie, Olimpia Colibar, Ciceronis Cumpănășoiu, Cristinel Gigi Șonea, Andra Cristina Șonea, Emil Tirziu, Biofilm formation of Staphylococcus, Streptococcus, Pasteurella and Neisseria strains Romanian Biotechnological Letters, 2015, 20(4): 10718 – 10726
  6. Rusu LC, Borţun CM, Tănăsie G, Podariu AC, Baderca F, Solovan C, Ardelean L The cytotoxicity of dental alloys studied on cell culture Rom J Morphol Embryol. 2014;55(1):111-5
  7. Ivan, V. Ordodi, A. Cean, D. Ilie, C. Panaitescu, Tanasie. Comparative study of the differentiation potential of rat bone marrow mesenchymal stem cells and rat muscle-derived stem cells Arch. Biol. Sci., Belgrade, 65 (4), 1307-1315, 2013
  8. Sava-Rosianu, A. C. Podariu, R. A. Popovici, G. Tanasie, L. Iliuta, R. Oancea. Alveolar bone repair using mesenchymal stem cells placed on granular scaffolds in a rat model. Digest Journal of Nanomaterials and Biostructures, 2013, 8, 1:303 – 311
  9. Ivan Boleman A, Tanasie G, Galuscan A, Cristea MI, Bojin FM, Panaitescu C, Paunescu V Studies regarding the in vitro wound healing potential of mouse dental pulp stem-like progenitor cells & Biotec. Eq., 2012; 26(1): 2781-5
  10. Sarandan H, Decun M, Paunescu V, Ordodi V, Bojin F, Hutu C, Zarcula S, Burian C, Tanasie G, Sarandan M Deoxynivalenol and Ochratoxin A inactivation in broiler chickens’ feed Romanian Biotechnological Letters, 2012; 17(6): 7825-7834
  11. Tanasie G, Bojin F, Ordodi V, Gruia A, Gavriliuc O, Cristea M, Dehelean C, Vintila R, Tatu C, Bunu C, Paunescu V Epithelization of skin lesions in animal model treated with mesenchymal stem cells and derivatives, Romanian Biotechnological Letters, 2011; 16(2): 6072-6080
  12. Bojin FM, Gavriliuc OI, Cristea MI, Tanasie G, Tatu CS, Panaitescu C, Paunescu V Telocytes within human skeletal muscle stem cell niche J Cell Mol Med. 2011; 15(10):2269-2272
  13. Bojin F, Ordodi V, Anghel S, Gruia A, Gavriliuc O, Georgescu R, Vintila R, Tatu C, Bunu C, Tatu CA, Tanasie G, Paunescu V Mesenchymal stem cells admix with biological scaffold heal bone defects in rat model Romanian Biotechnological Letters, 2011; 16(3): 6218-6225
  14. Paunescu V, Bojin FM, Tatu CA, Gavriliuc OI, Rosca A, Gruia AT, Tanasie G, Bunu C, Crisnic D, Gherghiceanu M, Tatu FR, Tatu CS, Vermesan S.Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences J Cell Mol Med. Mar 2011;15(3):635-46.
  15. Paunescu V, Deak E, Herman D, Siska IR, Tanasie G,Bunu C, Anghel S, Tatu CA, Oprea TI, Henschler , Rüster B, Bistrian R, Seifried E In vitro Differentiation of Human Mesenchymal Stem Cells to Epithelial Lineage J Cell Mol Med. 2007; 11(3):502-508
  16. Lazau, L. Mocanu, I. Miron, P. Sfirloaga, G. Tanasie, C. Tatu, A. Gruia, I. Grozescu. Consideration regarding the use of TiO2 doped nanoparticles in medicine, Digest Journal of Nanomaterials and Biostructures, 2007, 2 (3):257 – 263
  17. Ordodi VL, Mic FA, Mic AA, Tanasie G, Ionac M, Sandesc D, Paunescu Bone marrow aspiration from rats: a minimally invasive procedure Lab Anim (NY). 2006 May, 35(5):41-4
  18. Paunescu V, Suciu E, Tatu C, Plesa A, Herman D, Siska IR, Suciu C, Crisnic D, Nistor D, Tanasie G, Bunu C, Raica M.Endothelial cells from hematopoietic stem cells are functionally different from those of human umbilical vein, J Cell Mol Med, 2003 7(4):455-60

 

Affiliations

UMF “Victor Babes” Timisoara, Department III Functional Sciences, Physiology

OncoGen Center – SCJUPB Timisoara

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