Conf. Dr. CĂLIN TATU

Domenii de interes stiintific

Tema noastra principala de cercetare este medicina mediului si in particular relatia cauzala dintre anumiti factori poluanti si etiologia unor boli cronice de rinichi si a unor forme de cancer. Modelul principal de boala pe care il studiem este nefropatia endemica balcanica (BEN), o forma de insuficienta renala cronica limitata geografic la mai multe zone rurale din Peninsula Balcanica. Cauza (cauzele) principala a acestei boli nu se cunoaste, insa unul dintre factorii de mediu propusi este acidul aristolochic, o fitotoxina nefrotoxica si carcinogena. Scopul activitatii noastre de cercetare este de a identifica caile prin care populatia susceptibila din zonele cu BEN este expusa la aceasta toxina. Analizele efectuate prin metode sensibile de cromatografie si spectrometrie de masa au demostrat prezenta acidului aristolochic in diverse probe de mediu prelevate din zone endemice, insa relevanta toxicologica a cailor de expunere urmeaza a fi stabilita.

Pentru mai multe informatii, accesati: www.medicalgeology.ro

Publicatii stiintifice

1. Orem WH, Tatu CA, Varonka M, Lerch HE, Bates AL, Engle M, Crosby LM,  McIntosh J (2014) Organic substances in produced and formation water from unconventional natural gas extraction in coal and shale. Int J Coal Geol, Volume 126, 1 June 2014, Pages 20-31.
2. Paunescu V, Bojin FM, Gavriliuc OI, Taculescu EA, Ianos R, Ordodi VL, Iman VF, Tatu CA. (2014) Enucleation: a possible mechanism of cancer cell death. J Cell Mol Med. 2014 Mar 14. doi: 10.1111/jcmm.12271. [Epub ahead of print].
3. Maharaj SV, Orem WH, Tatu CA, Lerch HE 3rd, Szilagyi DN. (2013) Organic compounds in water extracts of coal: links to Balkan endemic nephropathy. Environ Geochem Health. 2013 Mar 21. [Epub ahead of print].
4. Pavlović NM, Maksimović V, Maksimović JD, Orem WH, Tatu CA, Lerch HE, Bunnell JE, Kostić EN, Szilagyi DN, Paunescu V. (2013) Possible health impacts of naturally occurring uptake of aristolochic acids by maize and cucumber roots: links to the etiology of endemic (Balkan) nephropathy. Environ Geochem Health.  Apr;35(2):215-26.
5. Paunescu V, Bojin FM, Tatu CA, Gavriliuc OI, Rosca A, Gruia AT, Tanasie G, Bunu C, Crisnic D, Gherghiceanu M, Tatu FR, Tatu CS, Vermesan S. Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences. J Cell Mol Med.  Mar;15(3):635-46.
6. Haider R, Ghauri MA, SanFilipo JR, Jones EJ, Orem WH, Tatu CA, Akhtar K,  Akhtar N (2013) Fungal degradation of coal as a pretreatment for methane production. Fuel, 104: 717-725.
7. Pavlovic NM, Orem WH, Tatu CA, Lerch HE, Bunnell JE, Feder GL, Kostic EN, Ordodi VL. (2008) The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: a new hypothesis. Food Chem Toxicol. 46(3):949-54.
8. Ordodi VL, Paunescu V, Ionac M, Sandesc D, Mic AA, Tatu CA, Mic FA. (2008) Artificial Device for Extracorporeal Blood Oxygenation in Rats, Artif Organs, 32(1):66-70 (5)
9. Paunescu V, Deak E, Herman D, Siska IR, Tanasie G, Bunu C, Anghel S, Tatu CA, Oprea TI, Henschler R, Rüster B, Bistrian R, Seifried E. (2007) In vitro Differentiation of Human Mesenchymal Stem Cells to Epithelial Lineage, J Cell Mol Med. 11(3):502-508
10. Orem WH, Tatu CA, Lerch HE,  Rice CA,  Bartos TT, Bates AL,  Tewalt S,  Corum MD. (2007) Organic compounds in produced waters from coalbed natural gas wells in the Powder River Basin, Wyoming, USA. Applied Geochem., 22(10):2240-2256.

11. Hadaruga NG, Hadaruga DI, Paunescu V, Tatu CA, Ordodi VL, Bandur G and Lupea AX. (2006) Thermal stability of the linoleic acid/α- and β-cyclodextrin complexes.  Food Chemistry 99(3): 500-508

1. Orem WH, Tatu CA, Lerch III HE, Maharaj SVM, Pavlovic N, Paunescu V, Dumitrascu V. (2004) Identification and Environmental Significance of the Organic Compounds in Water Supplies associated with a Balkan Endemic Nephropathy Region in Romania. J. Environ. Health Res. 3(2): 53-61

Afiliere

UMF “Victor Babes” Timisoara

Centrul Oncogen -SCJUT Timisoara