The indepth knowledge of the disease-causing allergens and their epitopes will be a cornerstone for the new developments, leading to the implementation of new and improved services to be provided after project completion.

Through the characterization of the relevant ragweed pollen allergens, INSPIRED will provide

  • Recombinant allergen-based kit tests for the specific diagnosis of ragweed allergy, which will improve allergic patient care.
  • Assays for the quantification of pollen allergens for) quality control of diagnostic allergen extracts, ii.) quality control of therapeutic allergen extracts, iii.) assessment of allergen exposure for allergen avoidance measures.

The usage of the complete panel of clinically relevant recombinant ragweed allergens and allergen- or epitope-specific antibodies proposed within INSPIRED is novel and has not been achieved so far, and will lead to the identification of possible candidate molecules for improving immunotherapy of ragweed pollen allergy which can be evaluated in large scale follow up projects, within HORIZON 2020, attracting private companies active in the field of innovative biotechnology.

The project will explore the feasibility of allergen-specific prophylactic strategies, trying to answer if the novel therapeutic approaches safely and efficiently improving ragweed allergy treatment are viable.


The potential beneficiaries are the allergic patients, their families, medical practitioners, but also the authorities playing roles in prevention and in the improvement of public health system efficiency.

For the allergic patients the new therapeutic and preventive approach will generate a better quality of life, with less clinical symptoms, less working days lost, and less costs raised by the therapy and the decreased working capacity, and in accordance of these, for their families, the societal and economic burden will be diminished.

For medical practitioners it will be expected to use the new diagnostic kit, which will increase the specificity and the reliability of the assessment of ragweed sensitisation. The approached theme is up to date and presents a great interest for the young researchers, proven by the involvement in the project of young post Docs and doctoral students.